Non-syndromic cleft lip and/or palate deformityAli KaramanErzurum Nenehatun Maternity Hospital, Erzurum
Non-syndromic cleft lip and/or palate (NSCLP) is a complex birth defect resulting from multiple genetic and environmental factors. Recently several genes causing NSCLP have been discovered. Some of them-namely Methylenetetrahydrofolate reductase (MTHFR), B-Cell leukemia/lymphoma 3(BCL3), Poliovirus receptor like-1, 2 (PVRL1 and PVRL2), T-box transcription factor-22 (TBX22), and Interferon regulatory factor-6 (IRF6) are responsible for causing NSCLP is one of the common congenital anomalies of the head and neck. This review aim to summarize some of important genetic and environmental factors in the aetiology of NSCLP. Keywords: Non-syndromic cleft lip and/ or palate, genes, environmental factors
Non-sendromik yarık dudak ve/veya damak deformitesiAli KaramanErzurum Nenehatun Kadın Doğum Hastanesi, Erzurum
Non-sendromik dudak ve/veya damak yarığı(NSDDY) çoklu genetik ve cevresel faktörlerin sonucu komplex doğumsal bir defekttir. Son zamanlarda NSDDY sebebi olan birçok gen bulunmuştur. Onların bazıları Methylenetetrahydrofolate reductase(MTHFR), B-Cell leukemia/lymphoma 3(BCL3), T-box transcription factor-22(TBX22), Poliovirus receptor like-1, 2 (PVRL1,2) ve İnterferon regulatory factor-6 (IRF6) genlerin sebep olduğu NSDDY, baş-boyun bölgesinin sık görülen konjenital anomalilerinden biridir. Bu derlemedeki amaç, NSDDY etiyolojisindeki önemli genetik ve çevresel faktörlerden bazılarını özetlemekdi. Anahtar Kelimeler: Nonsendromik yarık dudak ve/ veya damak, genler, çevresel faktörler
Ali Karaman. Non-syndromic cleft lip and/or palate deformity. Medeniyet Med J. 2009; 24(3): 134-137
Corresponding Author: Ali Karaman, Türkiye |
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