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Volume : 35 Issue : 1 Year : 2020



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Interpretation of falsely positive diagnosis in CK-MB Activity assay [Medeniyet Med J]
Medeniyet Med J. 2005; 20(4): 234-236

Interpretation of falsely positive diagnosis in CK-MB Activity assay

Yavuz Yalçın1, Hale Aral2, Aytekin Oğuz1, Güvenç Güvenen2
1SSK Goztepe Hospital, 2nd Internal Medicine Clinic, Istanbul
2SSK Istanbul Hospital Clinical Biochemistry Laboratory, Istanbul

CK isoenzymes provide more spesific information about injured tissue because of their tissue distribution. CK-linked immunuglobulins are recognized as macro CK because of their large molecular size. Clinical importance of macro CK lies in its potential to create confusion during the investigation of possible myocardial injury. Although the better approach is to measure CK-MB mass by using immunometric assay with monoclonal
antibodies for the M or B subunit, CK-MB mass method is also not free of interference with CK-BB, CK-MM, mitochondrial and macro CK. In this report, since we determined false positivity in two cases that applied to our department, we aimed to reveal particular points that will be taken into consideration in connection with interpretation of CKMB activity assay.

Keywords: Creatine kinase, CK isoenzymes, macro CK, CKMB


CK-MB aktivite ölçümünde yalancı pozitifliğin değerlendirilmesi

Yavuz Yalçın1, Hale Aral2, Aytekin Oğuz1, Güvenç Güvenen2
1SSK Göztepe Eğitim Hastanesi, 2. İç Hastalıkları Kliniği, İstanbul
2SSK İstanbul Eğitim Hastanesi Klinik Biyokimya Laboratuvarı, İstanbul

Anahtar Kelimeler: Kreatin kinaz, CK izoenzimleri, makro CK, CK-MB


Yavuz Yalçın, Hale Aral, Aytekin Oğuz, Güvenç Güvenen. Interpretation of falsely positive diagnosis in CK-MB Activity assay. Medeniyet Med J. 2005; 20(4): 234-236

Corresponding Author: Yavuz Yalçın, Türkiye


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