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Volume : 35 Issue : 4 Year : 2020



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Tuberculosis and Coronavirus disease 2019 (COVID-19) From Clinical Perspective: A Systematic Review [Medeniyet Med J]
Medeniyet Med J. 2020; 35(4): 338-343 | DOI: 10.5222/MMJ.2020.36775  

Tuberculosis and Coronavirus disease 2019 (COVID-19) From Clinical Perspective: A Systematic Review

Tri Hari Irfani1, Reynold Siburian2, Riska Nabila2, Tungki Pratama Umar2
1Public Health and Community Medicine Department, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia
2Medical Profession Student, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia

The aim of this review is to examine the effects of COVID-19 on Tuberculosis (TB) management and to highlight evidence of the extent of TB and COVID-19 co-infection. Current findings on TB and COVID-19 have been identified using six databases: Pubmed, Science Direct, Pubmed Central, MedXRiv, Wiley, and Google Scholar. This search in literature was conducted up to 8 May 2020. We included five studies that met the selection criteria. These selected studies have been performed in regions having various demographic characteristics including developed and developing countries, mainly China. The total number of participants in each study ranged from 24 to 203. The case fatality rate of patients with TB and COVID-19 co-infection was found to be high (6/49; 12.3 percent) while a combined diagnosis of TB and COVID-19 was found in 9/49 patients. This condition is linked to several complications, manifested as the need for ex novo oxygen supply, pneumothorax, and extreme hypoxia. Researches on BCG vaccination have shown that countries without vaccination policy are more likely to be seriously affected than those with BCG vaccination programs. COVID-19 infection in patients with TB or the lack of sufficient BCG vaccination may be associated with higher detrimental consequences, including mortality.

Keywords: BCG vaccine, COVID-19, Tuberculosis


Tri Hari Irfani, Reynold Siburian, Riska Nabila, Tungki Pratama Umar. Tuberculosis and Coronavirus disease 2019 (COVID-19) From Clinical Perspective: A Systematic Review. Medeniyet Med J. 2020; 35(4): 338-343

Corresponding Author: Tri Hari Irfani, Indonesia


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