Is There Any Possible Role Of Neurotrophin 3 in The Pathogenesis of Antrochoanal Polyp?

Objective: Antrochoanal polyp (ACP) is a benign soft tissue lesion arising from the inner wall of the maxillary sinus that extends into the nasal cavity and choanae. Although it was first explained by Killian in 1906, the underlying pathogenesis has not yet been fully understood. Neurotrophins were demonstrated to have a possible role in the pathogenesis of allergic rhinitis, idiopathic rhinitis and nasal polyps. To date there is no study that investigates the function of neuronal inflammation and neurotrophins in ACP development. The objective of this study was to investigate the possible effect of Neurotrophin-3 (NT-3) in ACP pathogenesis. Material and Methods: Twenty adult patients with ACPs who were undergone endoscopic sinus surgery in our department were taken as a study group. The control group included 15 patients with concha bullosa of middle concha who were undergone lateral removal operation. Nasal tissue NT-3 staining scores of study and control groups were determined by using immunohistochemistry. Blood NT-3 levels of both groups were detected by enzyme-linked immunosorbent assay. Results: There were no statistically significant differences between these two groups regarding tissue NT-3 staining scores (p=0.843) and blood NT-3 levels (p=0.463). In addition, no statistically significant correlation has been observed between tissue NT-3 staining scores and blood NT-3 levels in both ACP (p=0.578) and control (p=0.359) group patients. Conclusion: NT-3 related neuronal inflammation does not seem to have any role in ACP pathogenesis.