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Volume : 35 Issue : 1 Year : 2020



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Is There Any Possible Role Of Neurotrophin 3 in The Pathogenesis of Antrochoanal Polyp? [Medeniyet Med J]
Medeniyet Med J. 2020; 35(1): 40-46 | DOI: 10.5222/MMJ.2020.78889  

Is There Any Possible Role Of Neurotrophin 3 in The Pathogenesis of Antrochoanal Polyp?

Onur İsmi1, Cengiz Özcan1, Tuba Kara2, Gurbuz Polat3, Osman Erdoğan1, Senay Balcı Fidancı3, Yusuf Vayisoğlu1, Kemal Görür1
1Department Of Otorhinolaryngology, Faculty Of Medicine, University Of Mersin, Mersin/turkey
2Department Of Pathology, Faculty Of Medicine, University Of Mersin, Mersin/turkey
3Department Of Biochemistry, Faculty Of Medicine, University Of Mersin, Mersin/turkey

Objective: Antrochoanal polyp (ACP) is a benign soft tissue lesion arising from the inner wall of the maxillary sinus that extends into the nasal cavity and choanae. Although it was first explained by Killian in 1906, the underlying pathogenesis has not yet been fully understood. Neurotrophins were demonstrated to have a possible role in the pathogenesis of allergic rhinitis, idiopathic rhinitis and nasal polyps. To date there is no study that investigates the function of neuronal inflammation and neurotrophins in ACP development. The objective of this study was to investigate the possible effect of Neurotrophin-3 (NT-3) in ACP pathogenesis. Material and Methods: Twenty adult patients with ACPs who were undergone endoscopic sinus surgery in our department were taken as a study group. The control group included 15 patients with concha bullosa of middle concha who were undergone lateral removal operation. Nasal tissue NT-3 staining scores of study and control groups were determined by using immunohistochemistry. Blood NT-3 levels of both groups were detected by enzyme-linked immunosorbent assay. Results: There were no statistically significant differences between these two groups regarding tissue NT-3 staining scores (p=0.843) and blood NT-3 levels (p=0.463). In addition, no statistically significant correlation has been observed between tissue NT-3 staining scores and blood NT-3 levels in both ACP (p=0.578) and control (p=0.359) group patients. Conclusion: NT-3 related neuronal inflammation does not seem to have any role in ACP pathogenesis.

Keywords: Antrochoanal polyp, nasal polyp, neuronal inflammation, neurotrophin, neurotrophin 3, pathogenesis


Onur İsmi, Cengiz Özcan, Tuba Kara, Gurbuz Polat, Osman Erdoğan, Senay Balcı Fidancı, Yusuf Vayisoğlu, Kemal Görür. Is There Any Possible Role Of Neurotrophin 3 in The Pathogenesis of Antrochoanal Polyp?. Medeniyet Med J. 2020; 35(1): 40-46

Corresponding Author: Onur İsmi, Türkiye


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