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Volume : 34 Issue : 2 Year : 2019



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Acute disseminated encephalomyelitis [Medeniyet Med J]
Medeniyet Med J. 2006; 21(2): 99-101

Acute disseminated encephalomyelitis

Canan Kocaman1, Ü. Özlem Yolcu2, Gülseren Arslan3, Ender Asüyek3, Erdal Adal3
1Maternity and Children's Hospital Pediatric Neurology Clinic, Istanbul
2Maternity and Child Health Teaching Hospital, Istanbul
3Maternity and Pediatrics Hospital, Pediatric Neurology Clinic, Istanbul

Acute disseminated encephalomyelitis (ADEM) is an immunological disease which effects the white-matter of central nervous system (CNS) and which forms acute demyelinating multifocal lesions. Cases usually apply with neurological findings after a viral infection (CMV, EBV, mumps, measles) or inoculation. Mortality differs between 3-10 %. Because of unisolation of microorganism from brain tissue and seeing after inactive viral vaccine we think that immune mechanisms take part of role in pathogenesis. In CNS, it is assumed that immune damage is formed by T lymphocytes sensible to myeline. It is so
rare under 2-years. Clinical findigs are fever, headache, absent-minding, seizures, optic neuropaty, myelithis, hemiparesia. In diagnosis, the most important finding is bilateral, more than one and usually non-simetric signal increase areas in MR (T2-weighted). In cerebrospinal fluid, protein increase and mononuclear cells can be seen or it can be normal.
In treatment, we use steroids, intravenous immunglobulin (IVIG) and plasmaferesis. In this study we presented three cases of ADEM who applied to our clinic of neurology with the information of literatures.

Keywords: Acute disseminated encephalomiyelitis, childhood, treatment modalities


Akut dissemine ensefalomiyelit

Canan Kocaman1, Ü. Özlem Yolcu2, Gülseren Arslan3, Ender Asüyek3, Erdal Adal3
1SSK Bakırköy Doğumevi Kadın ve Çocuk Hastalıkları Eğitim Hastanesi Pediatrik Nöroloji Kliniği, İstanbul
2SSK Bakırköy Doğumevi Kadın ve Çocuk Hastalıkları Eğitim Hastanesi, İstanbul
3SSK Bakırköy Doğumevi Kadın ve Çocuk Hastalıkları Eğitim Hastanesi, Pediatrik Nöroloji Kliniği, İstanbul

Anahtar Kelimeler: Akut dissemine ensefalomiyelit, çocukluk dönemi, tedavi seçenekleri


Canan Kocaman, Ü. Özlem Yolcu, Gülseren Arslan, Ender Asüyek, Erdal Adal. Acute disseminated encephalomyelitis. Medeniyet Med J. 2006; 21(2): 99-101

Corresponding Author: Canan Kocaman, Türkiye


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