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The new approaches to relations of atherosclerosis and Chlamydia pneumoniae [Medeniyet Med J]
Medeniyet Med J. 2007; 22(1): 30-32

The new approaches to relations of atherosclerosis and Chlamydia pneumoniae

Bahadır Ceylan1, Aydın Mazlum2, Şule Ceylan3
1SSK Istanbul Hospital Clinical Microbiology and Infectious Diseases, Istanbul
2Safa Hospital Internal Medicine Clinic, Istanbul
3Marmara University Faculty of Medicine, Department of Nuclear Medicine, Istanbul

The obligate intracellular bacterium Chlamydia pneumoniae is one of the pathogens that have been linked to atherosclerosis. Serological studies found association between specific
IgA, IgG, IgM,circulating chlamydial immuncomplexes and atherosclerosis. Studies using with techniques such as immunocytochemistry, the polimerase chain reaction, and culture
showed that Chlamydia pneumoniae more common in atherosclerotic vessels rather than in normal vessels. The trials where patients with unstable angina or myocardial infarction
were given macrolide antibiotics reported beneficial effects in terms of reduction of further coronary events. Although the pathogenic mecanisms linking C. pneumoniae infection to atherosclerotic disorders have still not been fully explained, different mecanisms have been suggested: 1- The studies demonstrated that TNF, IL-1, and endotoxin increased by an infection can induce a state of insulin resistance. 2-The proatherogenic effects of Lp(a) may be enhanced and/or partly mediated through the formation of circulating immune complexes containing C. pneumoniae-specific IgG antibodies. 3- The immune response to bacterial infectionm generally may interact with chlamydial or human heat shock proteins in vessel walls, so exacerbating atherosclerosis. Our hypothesis is that infection plays a role in only a subset of patients with coronary artery disease. Cronic C. pneumoniae infection might aggravate the atherogenesis.

Keywords: Chlamydia pneumoniae, atherosclerosis


Chlamydia pneumoniae ateroskleroz ilişkisinde yeni yaklaşımlar

Bahadır Ceylan1, Aydın Mazlum2, Şule Ceylan3
1SSK İstanbul Eğitim Hastanesi Klinik Mikrobiyoloji ve İnfeksiyon Hastalıkları Kliniği, İstanbul
2Safa Hastanesi İç Hastalıkları Kliniği, İstanbul
3Marmara Üniversitesi Tıp Fakültesi Nükleer Tıp Anabilim Dalı, İstanbul

Anahtar Kelimeler: Chlamydia pneumoniae, ateroskleroz


Bahadır Ceylan, Aydın Mazlum, Şule Ceylan. The new approaches to relations of atherosclerosis and Chlamydia pneumoniae. Medeniyet Med J. 2007; 22(1): 30-32

Corresponding Author: Bahadır Ceylan, Türkiye


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