Leg ulcers associated with factor V Leiden mutation

Venous leg ulcers constitute 70 % of all leg ulcers which is a serious consequence of postthrombotic syndrome. Immobilisation, surgery, trauma, pregnancy, oral contraceptive drugs and some coagulation defects have been reported to be risk factors for venous thrombosis. Activated protein C resistance is the most frequent cause of hereditary thrombophilia which is mostly associated with a point mutation in factor V protein. Risk of venous thrombosis is substantially increased in patients with factor V Leiden mutation.
Herein we report two cases with factor V Leiden mutation which responded dramatically to oral anticoagulation therapy.

Keywords: Leg ulcers, factor V Leiden mutation

Faktör V Leiden mutasyonuna bağlı bacak ülserleri

Anahtar Kelimeler: Bacak ülseri, faktör V Leiden mutasyonu