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Leg ulcers associated with factor V Leiden mutation [Medeniyet Med J]
Medeniyet Med J. 2007; 22(4): 153-155

Leg ulcers associated with factor V Leiden mutation

Emek Kocatürk, Mukaddes Kavala, İlkin Zindancı, Zafer Türkoğlu, Melek Koç, Seyhan Beyhan
Goztepe Training and Research Hospital, Dermatology Clinic, Istanbul

Venous leg ulcers constitute 70 % of all leg ulcers which is a serious consequence of postthrombotic syndrome. Immobilisation, surgery, trauma, pregnancy, oral contraceptive drugs and some coagulation defects have been reported to be risk factors for venous thrombosis. Activated protein C resistance is the most frequent cause of hereditary thrombophilia which is mostly associated with a point mutation in factor V protein. Risk of venous thrombosis is substantially increased in patients with factor V Leiden mutation.
Herein we report two cases with factor V Leiden mutation which responded dramatically to oral anticoagulation therapy.

Keywords: Leg ulcers, factor V Leiden mutation


Faktör V Leiden mutasyonuna bağlı bacak ülserleri

Emek Kocatürk, Mukaddes Kavala, İlkin Zindancı, Zafer Türkoğlu, Melek Koç, Seyhan Beyhan
SB Göztepe Eğitim Araştırma Hastanesi Dermatoloji Kliniği, İstanbul

Anahtar Kelimeler: Bacak ülseri, faktör V Leiden mutasyonu


Emek Kocatürk, Mukaddes Kavala, İlkin Zindancı, Zafer Türkoğlu, Melek Koç, Seyhan Beyhan. Leg ulcers associated with factor V Leiden mutation. Medeniyet Med J. 2007; 22(4): 153-155

Corresponding Author: Emek Kocatürk, Türkiye


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