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Medeniyet Med J. 2005; 20(1): 51-53
Acute isoniaside intoxication
Aygen Türkmen, Ayşın Ersoy, Aysel Altan, Namigar Turgut, Zekeriya Ervatan, Sevda KızılırmakSSK Okmeydanı Training Hospital, IstanbulIsoniaside is a bactericidal drug used in the treatment of tuberculosis. Acute high doses can be fatal. Typical triad consists of recurrent convulsions resistant to anticonvulsants, metabolic acidosis with anion gap and coma. Pridoxine(B6) which is used for treatment is the specific antidot. If the administered dose isoniaside is unknown, 5 grams of pridoxin
is recommended IV. If the dose is known antidot is given in equal amounts. Pridoxin administration is the best way of treating convulsions and recovery from metabolic acidosis.
We present 2 cases regarding this subject.
Keywords: Isoniaside intoxication, pridoxine
Akut isoniasid intoksikasyonu
Aygen Türkmen, Ayşın Ersoy, Aysel Altan, Namigar Turgut, Zekeriya Ervatan, Sevda KızılırmakSSK Okmeydanı Eğitim Hastanesi, İstanbulAnahtar Kelimeler: İsoniazid intoksikasyonu, piridoksin
Corresponding Author: Aygen Türkmen, Türkiye
Manuscript Language: Turkish
Manuscript Language: Turkish