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Volume : 39 Issue : 2 Year : 2024



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A Meta-analysis of the Effect of Probiotic <i>Lactobacillus</i> sp. as Immunomodulating Inflammatory Responses [Medeniyet Med J]
Medeniyet Med J. 2024; 39(2): 122-131 | DOI: 10.4274/MMJ.galenos.2024.53822  

A Meta-analysis of the Effect of Probiotic Lactobacillus sp. as Immunomodulating Inflammatory Responses

Waode Fifin ERVINA1, Sri Pantja MADYAWATI3, Iswinarno Doso SAPUTRO4, Dodi SAFARI2, Rury Eryna PUTRI5, Salma ZULQAIDA1
1Postgraduate School of Universitas Airlangga, Master of Immunology Program, Surabaya, Indonesia
2National Research and Innovation Agency, Cibinong, Indonesia
3Post Graduate School of Universitas Airlangga, Surabaya, Indonesia
4Soetomo General Academic Hospital, Surabaya, Indonesia
5Postgraduate School of Universitas Airlangga, Master of Forensic Program, Surabaya, Indonesia

Lactobacillus sp. is considered an indispensable probiotic, and this probiotic has an effective role in maintaining the immune system. We evaluated the effect of the probiotic Lactobacillus sp. on modulating inflammation in several cases. In collecting the literature, we used databases from the Web of Science, the Cochrane Central Register of Controlled Trials, PubMed, and Embase. Studies that met the inclusion criteria were analyzed using Review Manager (version 5.4). A p-value of <0.05 of the total effect is considered statistically significant. Finally, 1895 references were retrieved and 20 were included in the meta-analysis. This meta-analysis suggested that most cases in this study were healthy elderly who received treatment with Lactobacillus sp. Lactobacillus sp. has a positive effect on B cells, eosinophils, IgE, NK cells, TNF-α, and IL-10. Lactobacillus could regulate the immune system by modulating inflammation in the healthy elderly.

Keywords: Good health and well-being, inflammation response, immune system, Lactobacillus sp.


Probiyotik Lactobacillus sp.’nin İmmünomodülatör Enflamatuvar Yanıtlar Üzerindeki Etkisinin Meta-analizi

Waode Fifin ERVINA1, Sri Pantja MADYAWATI3, Iswinarno Doso SAPUTRO4, Dodi SAFARI2, Rury Eryna PUTRI5, Salma ZULQAIDA1
1Postgraduate School of Universitas Airlangga, Master of Immunology Program, Surabaya, Indonesia
2National Research and Innovation Agency, Cibinong, Indonesia
3Post Graduate School of Universitas Airlangga, Surabaya, Indonesia
4Soetomo General Academic Hospital, Surabaya, Indonesia
5Postgraduate School of Universitas Airlangga, Master of Forensic Program, Surabaya, Indonesia

Lactobacillus sp. vazgeçilmez bir probiyotik olarak kabul edilimektedir ve bağışıklık sisteminin korunmasında etkili bir role sahiptir. Çalışmamızda probiyotik Lactobacillus sp.’nin çeşitli vakalarda enflamasyonu modüle etme üzerindeki etkisini değerlendirdik. Literatür taramasında Web of Science, Cochrane Central Register of Controlled Trials, PubMed ve Embase veri tabanlarını kullandık. Dahil edilme kriterlerini karşılayan çalışmalar Review Manager (versiyon 5.4) ile analiz edildi. Toplam etkinin p-değerinin <0,05 olması istatistiksel olarak anlamlı kabul edildi. Son olarak, toplam 1895 referansa ulaşıldı ve 20 tanesi meta-analize dahil edildi. Bu meta-analiz, bu çalışmadaki olguların çoğunun Lactobacillus sp. ile tedavi gören sağlıklı yaşlılar olduğunu göstermiştir. Lactobacillus sp. B hücreleri, eozinofiller, IgE, NK hücreleri, TNF-α ve IL-10 üzerinde olumlu bir etkiye sahiptir ve sağlıklı yaşlılarda enflamasyonu modüle ederek bağışıklık sistemini düzenleyebilir.

Anahtar Kelimeler: İyi sağlık ve iyilik hali, enflamasyon yanıtı, bağışıklık sistemi, Lactobacillus sp.


Waode Fifin ERVINA, Sri Pantja MADYAWATI, Iswinarno Doso SAPUTRO, Dodi SAFARI, Rury Eryna PUTRI, Salma ZULQAIDA. A Meta-analysis of the Effect of Probiotic Lactobacillus sp. as Immunomodulating Inflammatory Responses. Medeniyet Med J. 2024; 39(2): 122-131

Corresponding Author: Sri Pantja MADYAWATI, Indonesia


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