Using Liposomal Amphotericin B at Aspergillus OsteomyelitisMüferet Ergüven, Nurcan Özümüztoprak, Osman SaçarSSK Goztepe Hospital Children Clinic, Istanbul
Fungal organisms are increasingly recognized as serious and potentially fatal pathogens in the immunosuppressed host. There is a critical need for alternatives to amphotericin B as a treatment for such life-threatening fungal infections as invasive aspergillosis; because although amphotericin B is used to treat fungal infections that are resistant to other antifungal drugs, such as fluconazole and ketoconazole, there are severe toxic effects of amphotericin B include fever, chills, muscle pain, phlebitis, vomiting, potassium loss, kidney dysfunctions and anemia. Liposomal bounded amphotericin B also shows a distinctly lower toxic profile, even in higher concentrations in the plasma, than conventional amphotericin B. This report describes the successful treatment of an immunsupressed host suffering from severe aspergillus osteomyelitis and tuberculosis co-infection, using liposomal amphotericin B. Keywords: Liposomal amphotericin B, invasive aspergillosis, chronic granulomatosis disease
Aspergillus Osteomiyelitinde Lipozomal Amfoterisin B KullanımıMüferet Ergüven, Nurcan Özümüztoprak, Osman SaçarGöztepe SSK Eğitim Hastanesi, Çocuk Kliniği, İstanbul Anahtar Kelimeler: Lipozomal amphotericin B, invazif aspergilloz, kronik granülomatöz hastalık
Müferet Ergüven, Nurcan Özümüztoprak, Osman Saçar. Using Liposomal Amphotericin B at Aspergillus Osteomyelitis. Medeniyet Med J. 2003; 18(3): 191-192
Corresponding Author: Müferet Ergüven, Türkiye |
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