Home | Contact
     ISSN 2149-2042
     e-ISSN 2149-4606
 
 
 
Volume : 39 Issue : 2 Year : 2024



Current Issue Archive Popular Articles Ahead of Print




Index























Membership




Applications


 
Trachyspermum Ammi and Linum Usitatissimum are medicinal herbs used as hypolipidemic agents which protect against coronary artery disease [Medeniyet Med J]
Medeniyet Med J. 2016; 31(4): 282-286 | DOI: 10.5222/MMJ.2016.282  

Trachyspermum Ammi and Linum Usitatissimum are medicinal herbs used as hypolipidemic agents which protect against coronary artery disease

Ashraf Memon1, Majid Ali Hingoro1, Khalid Niaz1, Shah Murad1, Moosa Khan1, Abdul Qudoos2, Shahina Hakro2
1Departments of Pharmacology, Shaheed Zulfiqar Ali Bhutto Medical University
2Departments of Biochemistry, Shaheed Zulfiqar Ali Bhutto Medical University

Abnormal deviations ratio between subgroups of low- density lipoprotein (LDL) cholesterol and high-density lipoprotein cholesterol (HDL) in human body predisposes to the formation of atherogenic plaques which are main etiological factors for the development of Coronary Artery Disease (CAD). Many hypolipidemic herbs have been tested in the literature to prevent the occurrence of CAD. In this study we have used Trachyspermum Ammi (Ajwain; corn aniseed) and Linum Usitatissimum (Alsi, flaxseed) separately and in combination to investigate their anti-atherogenic and hypolipidemic features. Research was conducted at a Lahore General Hospital of Pakistan from February to June 2016. One hundred patients suffering from hyperlipidemia who were followed up in lipid research clinic of Jinnah Hospital, Lahore-Pakistan were enrolled in and approved written consent was taken from all patients. All patients were assigned to four different groups each, comprising of 25 patients. For three months, Group-I was treated with Ajwain, Group-II with Alsi, and Group-III with Ajwain plus Alsi. After three months therapy it was observed that Ajwain reduced LDL-cholesterol 23.77 mg/dl and increased HDL-cholesterol 3.3 mg/dl. Alsi reduced LDL-cholesterol 7.5 mg/dl and increased HDL-cholesterol 5.3 mg/dl. Whereas combination of both agents decreased LDL-cholesterol 16.1 mg/dl and increased HDL-cholesterol 6.6 mg/dl in three months therapy. It was concluded from this research work that Alsi and Ajwain given separately or in combination, have good enough potential to reduce LDL-cholesterol but are less potent effect on HDL-cholesterol in hyperlipidemic patients.

Keywords: Low density lipoprotein, high density lipoprotein, trachyspermum ammi, linum usitatissimum


Trachyspermum Ammi ve Linum Usitatissimum hipolipidemik ajan olarak kullanılan bitkilerdir ve koroner arter hastalığından korur

Ashraf Memon1, Majid Ali Hingoro1, Khalid Niaz1, Shah Murad1, Moosa Khan1, Abdul Qudoos2, Shahina Hakro2
1Departments of Pharmacology, Shaheed Zulfiqar Ali Bhutto Medical University
2Departments of Biochemistry, Shaheed Zulfiqar Ali Bhutto Medical University

Düşük dansiteli lipoprotein (LDL) ve yüksek dansiteli lipoprotein (HDL) kolesterol alt gruplarının oranlarındaki anormal sapmalar, insanlarda koroner arter hastalığı (KAH) gelişimi için temel bir etiyolojik faktör olan atreosklerotik plak oluşumuna zemin hazırlar. Literatürde KAH oluşumunun engellenmesine yönelik çeşitli hipolipidemik etkili bitkilerin test edildiği saptanmıştır. Biz de bu çalışmada, Trachyspermum Ammi (Ajvain, mısır anasonu) ve Linum Usitassimum (Alsi, keten tohumu) bitkilerinin ayrı ayrı ve beraber kullanımlarının anti-atherojenik ve hipolipidemik etkilerini araştırmayı planladık. Çalışma Pakistan Genel Hastanesi (General Hospital)’inde Şubat-Haziran 2016 tarihleri arasında yürütüldü. Çalışmaya, Pakistan Lahor Jinnah Hastanesi Lipid Araştırma Kliniğinde takip edilen yüz (100) hiperlipidemi hastası alındı. Olgular yazılı onamları alındıktan sonra her biri 25 hastadan oluşan dört farklı gruba atandı. Grup 1 için tek başına Ajvain, Grup 2 için tek başına Alsi, Grup 3 için ise Ajvain ve Alsi kombinasyon tedavisi 3 ay süre ile uygulandı. Üç aylık tedavi süresi sonrasında Ajvain grubunda LDL kolesterol seviyesinde 23.77 mg/dl düşüş ve HDL seviyesinde 3.3 mg/dl artış, Alsi grubunda LDL kolesterol seviyesinde 7,5 mg/dl düşüş ve HDL seviyesinde 5.3 mg/dl artış izlendi. İki ajanın kombine kullanıldığı grupta ise LDL kolesterol seviyesinde 16.1 mg/dl düşüş ile birlikte, HDL kolesterol seviyesinde 6.6 mg/dl artış gözlendi. Özetle bu çalışmada, hiperlipidemik hastalarda LDL kolesterolü düşürmede Ajvain ve Alsi’nin ayrı ayrı veya birlikte kullanılması durumunda güçlü bir etki gösterilmişken, HDL kolesterol seviyesini yükseltmede daha az etkili bulunmuştur

Anahtar Kelimeler: Düşük dansiteli lipoprotein, yüksek dansiteli lipoprotein, trachyspermum ammi, linum usitatissimum


Ashraf Memon, Majid Ali Hingoro, Khalid Niaz, Shah Murad, Moosa Khan, Abdul Qudoos, Shahina Hakro. Trachyspermum Ammi and Linum Usitatissimum are medicinal herbs used as hypolipidemic agents which protect against coronary artery disease. Medeniyet Med J. 2016; 31(4): 282-286

Corresponding Author: Ashraf Memon, Pakistan


TOOLS
Full Text PDF
Print
Download citation
RIS
EndNote
BibTex
Medlars
Procite
Reference Manager
Share with email
Share
Send email to author

Similar articles
PubMed
Google Scholar





 

  © 2024 MEDJ